Application of separable parameter space techniques to multi-tracer PET compartment modeling
نویسندگان
چکیده
منابع مشابه
Application of separable parameter space techniques to multi-tracer PET compartment modeling.
Multi-tracer positron emission tomography (PET) can image two or more tracers in a single scan, characterizing multiple aspects of biological functions to provide new insights into many diseases. The technique uses dynamic imaging, resulting in time-activity curves that contain contributions from each tracer present. The process of separating and recovering separate images and/or imaging measur...
متن کاملTracer Kinetic Modeling in PET.
Molecular imaging using PET provides a unique tool for noninvasively investigating the biochemistry of living organs. The wide range of radiolabeled molecules makes it possible to explore various biochemical, physiologic, and pharmacologic processes in vivo. Because each radiotracer is characterized by its particular kinetic behavior in the human body, the quantification of this behavior is a c...
متن کاملSphere-separable partitions of multi-parameter elements
We show the optimality of sphere-separable partitions for problems where n vectors in d-dimensional space are to be partitioned into p categories to minimize a cost function which is dependent in the sum of the vectors in each category; the sum of the squares of their Euclidean norms; and the number of elements in each category.We further show that the number of these partitions is polynomial i...
متن کاملCompartment modeling of dynamic brain PET--the impact of scatter corrections on parameter errors.
PURPOSE The aim of this study was to investigate the effect of scatter and its correction on kinetic parameters in dynamic brain positron emission tomography (PET) tumor imaging. The 2-tissue compartment model was used, and two different reconstruction methods and two scatter correction (SC) schemes were investigated. METHODS The gate Monte Carlo (MC) software was used to perform 2 × 15 full ...
متن کاملApplication of Tracer Techniques to Continuous-flow Toxicity Testing
-Frequent toxicant analyses are essential for good quality data in long-term continuous-flow tests. Due to the time consuming and costly chemical analyses, exposure levels are measured at best on a daily basis. These infrequent determinations may not detect variability in toxicant concentrations that could result in test failures. To minimize repetitive testing and improve data quality, a dye t...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Physics in Medicine and Biology
سال: 2016
ISSN: 0031-9155,1361-6560
DOI: 10.1088/0031-9155/61/3/1238